LABORATORY FEATURES OF ACUTE VIRAL HEPATITIS IN THE REPUBLIC OF KARAKALPAKSTAN
Keywords:
Acute viral hepatitis, HAV, HBV, HEV, clinical features, laboratory findings, Karakalpakstan.Abstract
Acute viral hepatitis (AVH) remains a significant public health challenge in the Republic of Karakalpakstan, an area characterized by unique ecological and environmental factors associated with the Aral Sea crisis. Environmental stressors, localized water quality issues, and regional socio-demographic dynamics profoundly influence the epidemiological and clinical manifestations of hepatotropic viruses. While the clinical presentations of AVH are well-documented, a comprehensive analysis of modern laboratory phenotypes, particularly the quantitative dynamics of specific enzymatic, pigment, and immunological markers within this specific geographic cohort, is essential to optimizing diagnostic pathways and predicting clinical outcomes.
References
1. World Health Organization. Hepatitis A. WHO; 2021.
2. World Health Organization. Hepatitis B. WHO; 2021.
3. Rein DB, Stevens GA, Theaker J, Wittenborn JS, Wiersma ST. The global burden of hepatitis E virus infections. Lancet Infect Dis. 2012;12(6):459–467.
4. Alter MJ. Epidemiology of hepatitis B in Europe and worldwide. J Hepatol. 2003;39 Suppl 1:S64–S69.
5. Wasley A, Hutin YJ, Bell BP. Hepatitis A in the era of vaccination. Epidemiol Rev. 2006;28:101–111.
6. Dienstag JL. Hepatitis B virus infection. N Engl J Med. 2008;359:1486–1500.
7. Khodjaev I, Mukhiddinov M, Tursunov A. Epidemiology of acute viral hepatitis in Central Asia. Central Asian J Med Sci. 2019;3(2):45–52.
