ETIOLOGY, PATHOGENESIS, AND RISK FACTORS OF SCLERODERMA IN NEWBORNS
- Authors
-
-
M. A. Khudzhanova
Department of Physiology, Pathophysiology, and Hygiene, Zarmed University, Samarkand,
Author
-
Z. G. Saidmurodova
Department of Physiology, Pathophysiology, and Hygiene, Zarmed University, Samarkand,
Author
-
M. M. Rahimova
Department of Physiology, Samarkand State Medical University, Samarkand,
Author
-
- Keywords:
- Neonatal scleroderma, sclerema neonatorum, fibrosis, autoimmune disease, microchimerism, pathogenesis, HLA genes.
- Abstract
-
Scleroderma (Systemic Sclerosis, SSc) is a chronic autoimmune connective tissue disease characterized by progressive fibrosis of the skin and internal organs, vasculopathy, and immune system dysregulation. In neonates, this condition is exceedingly rare and diagnostically challenging, frequently being confused with similar entities — sclerema neonatorum, scleredema, and subcutaneous fat necrosis (SCFN). This article provides a detailed review of the etiological factors, pathogenetic mechanisms, and clinically relevant risk factors of neonatal scleroderma. In particular, the roles of genetic susceptibility, maternal-fetal immunological interactions (microchimerism), infectious agents, and environmental influences are analyzed.
- References
-
1. Adigun R., Goyal A., Hariz A. Systemic Sclerosis (Scleroderma). StatPearls Publishing, 2024. NCBI Bookshelf.
2. Torok K.S., Li S.C., Jacobe H.M., et al. Immunopathogenesis of Pediatric Localized Scleroderma. Frontiers in Immunology, 2019;10:908.
3. Pattanaik D., Brown M., Postlethwaite B.C., Postlethwaite A.E. Pathogenesis of Systemic Sclerosis. Frontiers in Immunology, 2015;6:272.
4. Zeb A., Darmstadt G.L. Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management. Journal of Perinatology, 2008;28(7):453-460.
5. Alhalabi J., et al. Sclerema neonatorum in a premature newborn: A case report. Skin Health and Disease, 2023;3(5):e255.
6. Cleveland Clinic. Pediatric Systemic Scleroderma (Juvenile Scleroderma). Cleveland Clinic Foundation, 2026.
7. Stanford Medicine Children's Health. Scleroderma in Children. Lucile Packard Children's Hospital, 2025.
8.Johns Hopkins Medicine. Scleroderma Risk Factors. Johns Hopkins University, 2024.
9. Bhatia A., Khanna D. Scleroderma: An insight into causes, pathogenesis and treatment strategies. European Journal of Pharmaceutical Sciences, 2019;134:24-34.
- Downloads
- Published
- 2026-06-09
- Issue
- Vol. 2 No. 6 (2026)
- Section
- Articles
- License
-
This work is licensed under a Creative Commons Attribution 4.0 International License.
