CLINICAL AND BIOCHEMICAL FEATURES OF PATIENTS WITH DIFFERENT SERUM CALCIDIOL (25(OH)D) LEVELS
- Authors
-
-
Aripova Nargiza Nusratovna
Tashkent State Medical University, Republic of Uzbekistan.
Author
-
Tagaeva Mavjuda Khalmatovna
Tashkent State Medical University, Republic of Uzbekistan.
Author
-
Mansurov Jaxongir Nozimjon o'g'li
Tashkent State Medical University, Republic of Uzbekistan.
Author
-
Muxitdinjonov Abdulloh Maxmudjon o'g'li
Tashkent State Medical University, Republic of Uzbekistan.
Author
-
Mamatxonov Umarxon Baxodirjon o’g’li
Tashkent State Medical University, Republic of Uzbekistan.
Author
-
Abduxamidov Abdurasul Alisher o'g'li
Tashkent State Medical University, Republic of Uzbekistan.
Author
-
- Keywords:
- Chronic pancreatitis; vitamin D; calcidiol; 25-hydroxyvitamin D; exocrine pancreatic insufficiency; pancreatic elastase-1; calcium metabolism; osteopenia; osteoporosis.
- Abstract
-
Background. Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas characterized by irreversible structural changes, impaired exocrine function, and disturbances in nutrient absorption. Exocrine pancreatic insufficiency contributes to impaired absorption of fats and fat-soluble vitamins, particularly vitamin D. Vitamin D deficiency may aggravate metabolic disturbances, bone mineral disorders, and clinical manifestations of chronic pancreatitis. However, the relationship between serum calcidiol [25-hydroxyvitamin D, 25(OH)D] levels, exocrine pancreatic function, biochemical parameters, and clinical characteristics of CP remains insufficiently studied. Objective. To evaluate serum calcidiol [25(OH)D] levels in patients with chronic pancreatitis and to determine their relationship with biochemical parameters, calcium metabolism, pancreatic enzyme activity, fecal pancreatic elastase-1 levels, and clinical features of the disease.
- References
-
1.Egshatyan L.V., Dudinskaya E.N., Tkacheva O.N., Kashtanova D.A. Rol vitamina D v patogeneze khronicheskikh neinfektsionnykh zabolevaniy // Osteoporoz i osteopatii. – 2014. – T. 17, № 3. – S. 27–30.
2.Zazerskaya I.E. i dr. Vitamin D i reproduktivnoe zdorovye zhenshchiny. – SPb.: OOO «Eko-Vektor», 2017. – 151 s.
3.Ivashkin V.T., Maev I.V., Okhlobystin A.V. i dr. Rekomendatsii Rossiyskoy gastroenterologicheskoy assotsiatsii po diagnostike i lecheniyu khronicheskogo pankreatita // Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii. – 2014. – T. 24, № 4. – S. 70–97.
4.Kulikov V.A., Grebennikov I.N. Rol vitaminov D i K v razvitii sosudistoy kaltsifikatsii i ateroskleroza // Vestnik VGMU. – 2012. – T. 11, № 4. – S. 5–14.
5.Maev I.V., Bideeva T.V., Kucheryavyy Yu.A., Andreev D.N., Bueverov A.O. Farmakoterapiya khronicheskogo pankreatita s pozitsiy sovremennykh klinicheskikh rekomendatsiy // Terapevticheskiy arkhiv. – 2018. – T. 90, № 8. – S. 81–85.
6.Maev I.V., Kucheryavyy Yu.A., Andreev D.N. Ekzokrinnaya nedostatochnost podzheludochnoy zhelezy: klinicheskoe znachenie i podkhody k korrektsii s pozitsiy dokazatelnoy meditsiny // Terapevticheskiy arkhiv. – 2021. – T. 93, № 4. – S. 509–515.
7.Maev I.V., Kucheryavyy Yu.A., Andreev D.N., Bideeva T.V. Status pitaniya bolnykh khronicheskim pankreatitom // Terapevticheskiy arkhiv. – 2016. – T. 88, № 2. – S. 81–89.
8.Duggan S.N., Smyth N.D., Murphy A. et al. High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis. // Clin. Gastroenterol. Hepatol. 2014; 12: 219-228.
9.Frick T.W. Нerole of calcium in acute pancreatitis. // Surgery. 2012; 152: 157-163.
- Downloads
- Published
- 2026-06-09
- Issue
- Vol. 2 No. 6 (2026)
- Section
- Articles
- License
-
This work is licensed under a Creative Commons Attribution 4.0 International License.
