SALIVARY CHANGES AND THEIR ROLE IN ORAL PATHOLOGY IN CHILDREN UNDERGOING HEMODIALYSIS
Keywords:
Hemodialysis, chronic kidney disease, saliva, xerostomia, buffering capacity, children, dental caries, oral hygiene.Abstract
Background: Saliva plays a crucial role in maintaining oral homeostasis, including mechanical cleansing, buffering capacity, remineralization, and antimicrobial defense. In children with chronic kidney disease (CKD) undergoing hemodialysis, systemic disturbances significantly affect salivary function and composition, contributing to the development of oral diseases.
Objective: To evaluate salivary parameters and their association with oral pathology in children undergoing hemodialysis.
Materials and Methods: The study included 90 children aged 6–12 years divided into three groups: hemodialysis patients receiving comprehensive treatment (n=30), hemodialysis patients receiving standard treatment (n=30), and healthy controls (n=30). Salivary flow rate, pH, and buffering capacity were assessed alongside clinical indices (DMF, OHI-S, PI, PMA). Statistical analysis included Student’s t-test and Pearson correlation.
Results: Children undergoing hemodialysis demonstrated significantly reduced salivary flow rate and buffering capacity, along with altered pH levels (p<0.05). These changes were associated with increased caries intensity and poor oral hygiene. Significant correlations were found between salivary parameters and clinical indices.
References
1.Kshirsagar, A. V., Moss, K. L., Elter, J. R., Beck, J. D., & Offenbacher, S. (2005). Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk in Communities (ARIC) study. American Journal of Kidney Diseases, 45(4), 650–657.
2.Davidovich, E., Davidovits, M., Eidelman, E., Schwarz, Z., & Bimstein, E. (2005). Pathophysiology, therapy, and oral implications of renal failure in children and adolescents. Pediatric Dentistry, 27(2), 98–106.
3.Nunn, J. H., Sharp, J., Lambert, H. J., Plant, N. D., & Coulthard, M. G. (2000). Oral health in children with renal disease. Pediatric Nephrology, 14(10–11), 997–1001.
