THE IMPORTANCE OF THE ALA16VAL POLYMORPHIC LOCUS IN THE SOD2 GENE IN THE PROGRESS OF PROSTATE CANCER

• Tursunov Doniyor Muxammadjon ugli

  Republic Cancer Center of Uzbekistan, Andijan branch

  Author

Diagnosis and prognostic stratification of prostate cancer (PC) are traditionally based on three pillars: serum prostate-specific antigen (PSA) levels, clinical staging according to the TNM system, and the Gleason score according to biopsy data. Despite their widespread use and inclusion in international guidelines, these tools have significant limitations that lead to problems of overdiagnosis, overtreatment, and, in some cases, underestimation of disease aggressiveness. In modern urological oncology, there is an urgent need to integrate new, more accurate biomarkers for a personalized approach to patient management.
The SOD2 gene (superoxide dismutase 2) encodes an enzyme that protects cells from damage caused by oxidative stress and converts toxic reactive oxygen species (ROS) into safer molecules. It is a major protein in the mitochondrial matrix, where it detoxifies byproducts of energy metabolism. Mutations in SOD2 may be associated with a variety of diseases, including cancer, as well as accelerated aging.

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