PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) AND NON-INVASIVE PRENATAL TESTING (NIPT) AS KEY COMPONENTS OF CONTEMPORARY PREGNANCY MANAGEMENT

• Jurayev Islombek Izzatullo ugli

  1st Year Clinical Resident, Obstetrics and Gynecology

  Author

• Toshmurodova Yorkinoy Rustam kizi

  2nd Year Clinical Resident, Obstetrics and Gynecology

  Author

• Rakhmonova Mohigul Shodikulovna

  1st Year Clinical Resident, Obstetrics and Gynecology Candidate of Medical Sciences, Professor Agababyan Larisa Rubenovna Head of the Department of Postgraduate Education in Obstetrics and Gynecology

  Author

• Agababyan Larisa Rubenovna

  Candidate of Medical Sciences, Professor Head of the Department of Postgraduate Education in Obstetrics and Gynecology

  Author

• Khudoyarova Dildora Rakhimovna

  Candidate of Medical Sciences, Professor Head of Department of Obstetrics and Gynecology No. 1 Samarkand State Medical University, Samarkand, Uzbekistan

  Author

The rapid development of reproductive genetics has substantially influenced current approaches to pregnancy planning and prenatal care. Preimplantation genetic testing for aneuploidy (PGT-A) and non-invasive prenatal testing (NIPT) are innovative screening methods designed to identify chromosomal abnormalities at different stages of human development. PGT-A is performed prior to embryo implantation during assisted reproductive technology cycles, while NIPT allows early assessment of fetal chromosomal status through maternal blood analysis. The combined use of these methods contributes to improved reproductive outcomes, reduction of pregnancy loss, and optimization of individualized pregnancy management. This article provides an analytical overview of the principles, clinical significance, advantages, limitations, and ethical aspects of PGT-A and NIPT in modern obstetric practice.

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