INVESTIGATING THE POTENTIAL GENETIC ASSOCIATION OF SALIVARY AND TONGUE MICROBIOTA WITH PERIODONTITIS: A MENDELIAN RANDOMIZATION STUDY

Authors

  • Djalilova Fariza Rasuljanovna Tashkent State Medical University Department: Propaedeutics of Orthopedic Dentistry Author
  • Jamshid Qobilovich Abdulakhatov Tashkent State Medical University Department: Propaedeutics of Orthopedic Dentistry Author
  • Safira Abdisalomovna Karimova Tashkent State Medical University Department: Propaedeutics of Orthopedic Dentistry Author

Keywords:

Mendelian randomization, Oral microbiome, Periodontitis, Tongue microbiota.

Abstract

Chronic periodontitis (CP) is characterized by subgingival microbial dysbiosis and demonstrates distinct microbial profiles; however, clear causal relationships with microbiomes from separate oral regions remain poorly defined. Genome-wide association study (GWAS) data for CP and oral microbial communities were obtained from a large European cohort and the China National GeneBank DataBase (CNGBdb), respectively. Using single-nucleotide polymorphisms (SNPs) as genetic instruments, Mendelian randomization (MR) analyses were performed via the inverse-variance weighted (IVW) method. Analytical procedures were executed using the ‘TwoSampleMR’ package (version 0.6.4) in R. Sensitivity analyses were conducted to confirm result robustness and limit horizontal pleiotropy.

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Published

2026-01-24

Issue

Vol. 2 No. 1 (2026)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

INVESTIGATING THE POTENTIAL GENETIC ASSOCIATION OF SALIVARY AND TONGUE MICROBIOTA WITH PERIODONTITIS: A MENDELIAN RANDOMIZATION STUDY. (2026). Eureka Journal of Health Sciences & Medical Innovation, 2(1), 433-442. https://eurekaoa.com/index.php/5/article/view/249

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