IMMUNOHISTOCHEMICAL ASPECTS OF CD 31 (PECAM-1) INTEGRIN ACTIVATION IN VASCULAR ENDOTHELIUM DURING RESTENOSIS AFTER CORONARY ARTERY STENTING

• Muydinov Javlonbek Ibrokhimovich

  Associate Professor of the Department of Pathophysiology and Pathological Anatomy, Fergana Public Health Medical Institute, PhD

  Author

It was found that during the restenosis process occurring in the poststen ting period of coronary arteries, the activation of integrins in the endothelium and the subsequent interaction of activated cell-surface transmembrane heterodimers with the extracellular matrix lead to increased cell adhesion. Consequently, this results in the transendothelial migration of inflammatory elements, including leukocytes, to the affected areas, contributing to the formation of inflammatory signs in the vessel wall. It was determined that these processes specifically lead to the development of focal vasculitis in the vessel wall after coronary stenting, intensification of reparative regeneration in these areas, active proliferation of fibroblasts, and ultimately, vascular restenosis.

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