THE COURSE OF PREGNANCY AND THE DEVELOPMENT OF OBSTETRIC COMPLICATIONS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
- Authors
-
-
Najmutdinova D. K.
Tashkent State Medical University
Author
-
Ilhomova K. A.
Tashkent State Medical University
Author
-
- Keywords:
- Systemic lupus erythematosus; pregnancy; obstetric complications; lupus nephritis; antiphospholipid syndrome; maternal outcomes; fetal outcomes
- Abstract
-
Systemic lupus erythematosus is a chronic autoimmune disease that predominantly affects women of reproductive age, making pregnancy management a major clinical concern. Pregnancy in patients with systemic lupus erythematosus is associated with an increased risk of maternal, fetal, and neonatal complications resulting from immune dysregulation, vascular involvement, and organ damage. Disease activity at conception, lupus nephritis, antiphospholipid syndrome, and cardiopulmonary involvement are among the principal factors contributing to adverse pregnancy outcomes. Maternal complications frequently include disease flares, hypertensive disorders, renal deterioration, and thromboembolic events, while fetal complications encompass pregnancy loss, intrauterine growth restriction, preterm delivery, and neonatal lupus manifestations. Evidence indicates that favorable pregnancy outcomes are more likely when conception occurs during periods of disease remission or stable low activity. Comprehensive preconception evaluation, individualized risk stratification, and close multidisciplinary monitoring throughout pregnancy and the postpartum period are essential for minimizing complications. An integrated clinical approach allows many women with systemic lupus erythematosus to achieve successful pregnancy outcomes despite the high-risk nature of the condition.
- References
-
1.Ameer, M. A., Chaudhry, H., Mushtaq, J., Khan, O. S., Babar, M., Hashim, T., ... & Khan, O. S. (2022). An overview of systemic lupus erythematosus (SLE) pathogenesis, classification, and management. Cureus, 14(10).
2.Efthimiou, P., Kadavath, S., & Mehta, B. (2014). Life-threatening complications of adult-onset Still’s disease. Clinical rheumatology, 33(3), 305-314.
3.Nusbaum, J. S., Mirza, I., Shum, J., Freilich, R. W., Cohen, R. E., Pillinger, M. H., ... & Buyon, J. P. (2020, February). Sex differences in systemic lupus erythematosus: epidemiology, clinical considerations, and disease pathogenesis. In Mayo Clinic Proceedings (Vol. 95, No. 2, pp. 384-394). Elsevier.
4.Williams, D. R. (2002). Racial/ethnic variations in women's health: the social embeddedness of health. American journal of public health, 92(4), 588-597.
5.Galoppini, G., Marangoni, A., Cirilli, F., Ruffilli, F., Garaffoni, C., Govoni, M., ... & Bortoluzzi, A. (2023). Optimizing patient care: a systematic review of multidisciplinary approaches for SLE management. Journal of Clinical Medicine, 12(12), 4059.
6.Sangah, A. B., Jabeen, S., Hunde, M. Z., Devi, S., Mumtaz, H., & Shaikh, S. S. (2023). Maternal and fetal outcomes of SLE in pregnancy: a literature review. Journal of Obstetrics and Gynaecology, 43(1), 2205513.
7.Moroni, G., & Ponticelli, C. (2016). Pregnancy in women with systemic lupus erythematosus (SLE). European journal of internal medicine, 32, 7-12.
8.He, W. R., & Wei, H. (2020). Maternal and fetal complications associated with systemic lupus erythematosus: an updated meta-analysis of the most recent studies (2017–2019). Medicine, 99(16), e19797.
9.Li, J., Li, Z., Yu, L., & Su, J. (2021). Maternal and neonatal outcomes of pregnancy complicated with Systemic Lupus Erythematosus. Food Science and Technology, 42, e56921.
10.Mehta, B., Luo, Y., Xu, J., Sammaritano, L., Salmon, J., Lockshin, M., ... & Ibrahim, S. (2019). Trends in maternal and fetal outcomes among pregnant women with systemic lupus erythematosus in the United States: a cross-sectional analysis. Annals of internal medicine, 171(3), 164-171.
11.Galoppini, G., Marangoni, A., Cirilli, F., Ruffilli, F., Garaffoni, C., Govoni, M., ... & Bortoluzzi, A. (2023). Optimizing patient care: a systematic review of multidisciplinary approaches for SLE management. Journal of Clinical Medicine, 12(12), 4059.
12.Jack, B. W., Atrash, H., Coonrod, D. V., Moos, M. K., O'Donnell, J., & Johnson, K. (2008). The clinical content of preconception care: an overview and preparation of this supplement. American journal of obstetrics and gynecology, 199(6), S266-S279.
13.
Thung, S. F., & Norwitz, E. R. (2010). Postpartum care: we can and should do better. American Journal of Obstetrics & Gynecology, 202(1), 1-4.
14.Wang, X., & Xia, Y. (2019). Anti-double stranded DNA antibodies: origin, pathogenicity, and targeted therapies. Frontiers in immunology, 10, 1667.
15.Winocour, P. H. (2018). Diabetes and chronic kidney disease: an increasingly common multi‐morbid disease in need of a paradigm shift in care. Diabetic Medicine, 35(3), 300-305.
16.Hsu, C. Y., McCulloch, C. E., Darbinian, J., Go, A. S., & Iribarren, C. (2005). Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease. Archives of internal medicine, 165(8), 923-928.
17. El Miedany, Y., & Palmer, D. (2021). Rheumatology-led pregnancy clinic: patient-centred approach. Clinical Rheumatology, 40(10), 3875-3882.
18.Bramham, K., Soh, M. C., & Nelson-Piercy, C. (2012). Pregnancy and renal outcomes in lupus nephritis: an update and guide to management. Lupus, 21(12), 1271-1283.
19. Schreiber, K., Sciascia, S., De Groot, P. G., Devreese, K., Jacobsen, S., Ruiz-Irastorza, G., ... & Hunt, B. J. (2018). Antiphospholipid syndrome. Nature reviews Disease primers, 4(1), 1-20.
- Downloads
- Published
- 2026-02-11
- Issue
- Vol. 2 No. 2 (2026)
- Section
- Articles
- License
-
This work is licensed under a Creative Commons Attribution 4.0 International License.
