PATHOLOGICAL CHANGES IN DENTAL HARD TISSUES DURING TOOTH DEVELOPMENT: GENETIC AND MOLECULAR ASPECTS
- Authors
-
-
Karimova Safira Abdisalomovna
Organization: Tashkent State Medical University Department: Propaedeutic of Orthopedic Dentistry
Author
-
- Keywords:
- Dental hard tissues, amelogenesis, dentinogenesis, genetDental hard tissues, amelogenesis, dentinogenesis, genetic factors, dentistry.ic factors, dentistry.
- Abstract
-
Pathological changes in dental hard tissues formed during tooth development represent a significant problem in modern dentistry. Disturbances in amelogenesis and dentinogenesis may result from genetic, molecular, and systemic factors that affect mineralization processes. This narrative review summarizes current data on the genetic mechanisms underlying pathological changes in enamel and dentin, discusses major hereditary dental disorders, and highlights the prospects of molecular genetic diagnostics in clinical dental practice.
- References
-
1.
Abduazimov, A. A., & Rakhimov, S. S. (2018). Genetic aspects of enamel formation disorders. Dentistry of Uzbekistan, 3, 12–16.
2.
Karimov, U. K., & Tursunova, M. N. (2020). Hereditary diseases of dental hard tissues in children. Bulletin of Medical Sciences of Uzbekistan, 4, 45–49.
3.
Aldred, M. J., Savarirayan, R., & Crawford, P. J. (2003). Amelogenesis imperfecta: A classification and catalogue for the 21st century. Oral Diseases, 9(1), 19–23.
4.
Bartlett, J. D. (2013). Dental enamel development: Proteinases and their enamel matrix substrates. ISRN Dentistry, 2013, 684607.
5.
Hu, J. C. C., Chun, Y. H. P., Al Hazzazzi, T., & Simmer, J. P. (2007). Enamel formation and amelogenesis imperfecta. Cells Tissues Organs, 186(1), 78–85.
6.
Smith, C. E. (1998). Cellular and chemical events during enamel maturation. Critical Reviews in Oral Biology & Medicine, 9(2), 128–161.
7.
Wright, J. T., Carrion, I. A., & Morris, C. (2015). The molecular basis of hereditary enamel defects. Journal of Dental Research, 94(1), 52–61.
8.
Hall, R. K. (2009). Pediatric Orofacial Medicine and Pathology. Springer.
9.
Abduazimov, A. A., & Rakhimov, S. S. (2018). Genetic aspects of enamel formation disorders. Dentistry of Uzbekistan, 3, 12–16.
- Downloads
- Published
- 2026-02-20
- Issue
- Vol. 2 No. 2 (2026)
- Section
- Articles
- License
-
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
Most read articles by the same author(s)
- Karimova Safira Abdisalomovna, METABOLIC DISORDERS AS A FACTOR IN PATHOLOGICAL CHANGES OF DENTAL HARD TISSUES DURING TOOTH DEVELOPMENT , Eureka Journal of Health Sciences & Medical Innovation: Vol. 2 No. 2 (2026)