MORPHOFUNCTIONAL CORRELATION OF DETOXIFICATION ENZYME ACTIVITY IN LIVER TISSUE AND HEPATOCYTE APOPTOSIS IN EXPERIMENTAL GASTRIC ULCER

Authors
  • Sanjаr Allaberganov

    Independent researcher, Department of Pathomorphology, Urgench State Medical Institute, Urgench, Uzbekistan

    Author

  • Dilorom Adilbekova

    Professor, Department of Anatomy and Clinical Anatomy, Tashkent State Medical University, Tashkent, Uzbekistan

    Author

Keywords:
Experimental gastric ulcer, liver detoxification, cytochrome P450 2E1, glutathione-S-transferase, apoptosis, hepatocytes, Caspase-3, TUNEL assay.
Abstract

Objective: Experimental gastric ulcer is known to cause systemic metabolic disturbances affecting distant organs, including the liver. This study aimed to evaluate the morphofunctional relationship between the activity of hepatic detoxification enzymes and the development of hepatocyte apoptosis in an experimental model of gastric ulcer.

References

1. Nazarova M.B., Adilbekova D.B., Akhrorov A.A., Toshpulatov S.S., Rustamova F.O. The morphological and morphometrical state of the liver’s in offspring born to mothers with chronic toxic hepatitis under conditions of medication correction before pregnancy (experimental study)// Central Asian Journal of Medicine. eISSN: 2181-1326. 2025. p. 77-84.

2. Nazarova M.B., Adilbekova D.B., Akhrorov A.A., Toshpulatov S.S., Rustamova F.O. The morphological and morphometric state of the liver’s vascular tissue structures in the offspring of intact experimental rats during postnatal ontogeny dynamics (experimental study)// Central Asian Journal of Medicine. eISSN: 2181 1326. 2025. p. 50-57.

3. Chen F., Li Q., Xu X., Wang F. (2024). Selenium attenuates ethanol-induced hepatocellular injury by regulating ferroptosis and apoptosis. Turkish Journal of Gastroenterology, 35(10), 778–786.

4. Hao Z., Liu X., He H., Wei Z., Shu X., Wang J., Sun B., Zhou H., Wang J., Niu Y. (2024). CYP2E1 deficit mediates cholic acid-induced malignant growth in hepatocellular carcinoma cells. Molecular Medicine, 30(1), 79.

5. Kim J., Sim Y., Kim D., Kwon J., Lee S., Rungratanawanich W., Jung J., Lee Y., Hyun S., Seo K. (2025). Ginseng-derived exosome-like nanovesicles protect against liver fibrosis by regulating TIMP2 pathways and gut dysbiosis. Asian Journal of Pharmaceutical Sciences, 20(6), 101105.

6. Lan T., Hu Y., Hu F., Li H., Chen Y., Zhang J., Yu Y., Jiang S., Weng Q., Tian S. (2022). Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. Journal of Hepatology, 76(2), 407–419.

7. Mun H., Lee S., Choi S., Jeong J.H., Ko S., Chun Y.L., Deaton B., Yeager C.T. (2024). Targeting of CYP2E1 by miRNAs in alcohol-induced intestinal injury. Molecular Cells, 47(7), 100074.

8. Wang K., Tan W., Liu X., Deng L., Huang L., Wang X., Gao X. (2021). New insight and potential therapy for NAFLD: CYP2E1 and flavonoids. Biomedicine & Pharmacotherapy, 137, 111326.

9. Wu Y., Xu Y., Cai H., Hua Z., Luo M., Hu L., Zhou N., Wang X., Li W. (2025). Overexpression of SULT1E1 alleviates cholestatic liver damage induced by Psoraleae Fructus. Chinese Medicine, 17(2), 392–403.

10. Zhang Y., Lu H., Ji H., Li Y. (2023). Hypoxia-induced apoptosis of gastric mucosal epithelial cells in portal hypertensive gastropathy. Digestive and Liver Disease, 55(9), 1198–1206.

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2026-03-09
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How to Cite

MORPHOFUNCTIONAL CORRELATION OF DETOXIFICATION ENZYME ACTIVITY IN LIVER TISSUE AND HEPATOCYTE APOPTOSIS IN EXPERIMENTAL GASTRIC ULCER. (2026). Eureka Journal of Health Sciences & Medical Innovation, 2(3), 31-37. https://eurekaoa.com/index.php/5/article/view/580