CLINICAL EFFICACY AND SAFETY OF THE COMBINATION OF ROSUVASTATIN AND EZETIMIBE IN THE TREATMENT OF DYSLIPIDEMIA

Authors

  • Karjavova Maxliyo Narbekovna Assistant Lecturer, Department of Internal Diseases, Chirchik Branch of Tashkent State Medical University Author
  • Rustamova Yulduz Alisherovna Assistant Lecturer, Department of Internal Diseases, Chirchik Branch of Tashkent State Medical University Author
  • Xasanov Qobul Xakimovich Head of the Therapy Department, Chirchik City Association Author

Keywords:

Rosuvastatin, ezetimibe, dyslipidemia, LDL cholesterol, cardiovascular outcomes, safety profile.

Abstract

This article analyzes the clinical efficacy and safety of the combination of rosuvastatin and ezetimibe in the treatment of dyslipidemia. Dyslipidemia is a major risk factor for cardiovascular disease, and while statins are first-line therapy for lowering LDL cholesterol, monotherapy may be insufficient in some patients. Clinical studies demonstrate that the combination therapy provides greater LDL cholesterol reduction compared to monotherapy, with a safety profile similar to statins alone.

References

1.

Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. NEJM. 2015;372(25):2387–2397.

2.

Kim BK, Hong SJ, Lee YJ, et al. Rosuvastatin plus Ezetimibe versus High-Intensity Statin Monotherapy in Patients with Coronary Artery Disease (RACING trial). The Lancet. 2022;399(10338):2061–2073.

3.

Ballantyne CM, Blazing MA, King TR, Brady WE, Palmisano J. Efficacy and Safety of Ezetimibe Co-Administered with Statins. Current Atherosclerosis Reports. 2004;6(5):379–385.

4.

Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB. Ezetimibe: A Review of its Metabolism, Pharmacokinetics and Drug Interactions. Clinical Pharmacokinetics. 2005;44(5):467–494.

5.

Stone NJ, Robinson JG, Lichtenstein AH, et al. 2018 ACC/AHA Guideline on the Management of Blood Cholesterol. JACC. 2019;73(24):e285–e350.

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Published

2026-03-09

Issue

Section

Articles

How to Cite

CLINICAL EFFICACY AND SAFETY OF THE COMBINATION OF ROSUVASTATIN AND EZETIMIBE IN THE TREATMENT OF DYSLIPIDEMIA. (2026). Eureka Journal of Health Sciences & Medical Innovation, 2(3), 38-41. https://eurekaoa.com/index.php/5/article/view/582