BIOPHYSICAL MODELING OF THE ELASTICITY AND VISCOELASTICITY OF SOFT HUMAN TISSUES USING SILICONE ANALOGUES: AN EXPERIMENTAL AND COMPUTATIONAL APPROACH
- Authors
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Soyibnazarova Raykhona
Student, Tashkent State Medical University Tashkent, Uzbekistan
Author
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Rahmatova Rayhona
Student, Tashkent State Medical University Tashkent, Uzbekistan
Author
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Abdujabbarova Umida Mashrukovna
Scientific Supervisor, Senior Lecturer of Department Biomedical Engineering, Informatics and Biophysics Tashkent State Medical University, Tashkent, Uzbekistan
Author
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- Keywords:
- silicone phantom; Young's modulus; viscoelasticity; mechanical hysteresis; soft tissue mechanics; BioMech Analyzer; biofidelity.
- Abstract
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The mechanical characterization of soft biological tissues remains a significant challenge in biomedical engineering due to ethical and practical constraints in obtaining living tissue specimens. This study presents an experimental and computational framework employing commercial silicone elastomers as biofidelic analogues for soft human tissues. Uniaxial tensile tests were performed using a custom low-cost setup; Young's moduli ranging from 0.06 to 0.47 MPa were measured across strains of 0.23–2.36, values that align closely with published mechanical data for human adipose, breast, and liver tissues. Loading–unloading cycles were conducted to characterize mechanical hysteresis and viscoelastic energy dissipation. Additionally, a novel web application, BioMech Analyzer, was developed to automate stress–strain computation, hysteresis loop visualization, and real-time comparison of experimental moduli against a curated human tissue database via a "Tissue Matching Score" index. Results confirm that commercial silicone can serve as an accessible, tunable phantom material for biophysical modeling, with direct implications for medical device testing, surgical training, and educational biophysics laboratories.
- References
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1. Kamal, I., Abdul Razak, H. R., Supion, N., Abdul Karim, M. K., Osman, N. H., & Norkhairunnisa, M. (2021). Structural, mechanical, and dielectric properties of polydimethylsiloxane and silicone elastomer for the fabrication of clinical-grade kidney phantom. Applied Sciences, 11(3), 1175. https://doi.org/10.3390/app11031175
2. Payne, T., Mitchell, S. R., Bibb, R., & Waters, M. (2014). The evaluation of new multi-material human soft tissue simulants for sports impact surrogates. Journal of the Mechanical Behavior of Biomedical Materials, 41, 336–356. https://doi.org/10.1016/j.jmbbm.2014.09.018
3. Heinrichs, V., Dieluweit, S., Stellbrink, J., Pyckhout-Hintzen, W., Hersch, N., Richter, D., & Merkel, R. (2018). Chemically defined, ultrasoft PDMS elastomers with selectable elasticity for mechanobiology. PLOS ONE, 13(9), e0195180. https://doi.org/10.1371/journal.pone.0195180
4. Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020). Effects of extracellular matrix viscoelasticity on cellular behaviour. Nature, 584(7822), 535–546. https://doi.org/10.1038/s41586-020-2612-2
5. Zhang, C., Gou, X., & Xiao, R. (2021). Hysteresis in glass microsphere filled elastomers under cyclic loading. Polymer Testing, 95, 107081. https://doi.org/10.1016/j.polymertesting.2021.107081
6. Zamprogno, P., Thoma, G., Cencen, V., Ferrari, D., Putz, B., Michler, J., Fantner, G., & Guenat, O. T. (2021). Mechanical properties of soft biological membranes for organ-on-a-chip assessed by bulge test and AFM. ACS Biomaterials Science & Engineering. https://doi.org/10.1021/acsbiomaterials.0c00515
7. Chanda, A. (2018). Biomechanical modeling of human skin tissue surrogates. Biomimetics, 3(3), 18. https://doi.org/10.3390/biomimetics3030018
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- Published
- 2026-03-11
- Issue
- Vol. 2 No. 3 (2026)
- Section
- Articles
- License
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This work is licensed under a Creative Commons Attribution 4.0 International License.
