COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF TAMSULOSIN AND SILODOSIN IN PATIENTS WITH UROLITHIASIS: URETERAL STONES IN DIFFERENT SEGMENTS
- Authors
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Kasimov S. S.
Tashkent state medical university, Uzbekistan, Tashkent. State Institution "Republican Specialized Scientific and Practical Medical Center of Urology", Uzbekistan, Tashkent
Author
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Abdusatarov A. U.
Tashkent state medical university, Uzbekistan, Tashkent. State Institution "Republican Specialized Scientific and Practical Medical Center of Urology", Uzbekistan, Tashkent
Author
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Abdukarimov O. O.
Tashkent state medical university, Uzbekistan, Tashkent. State Institution "Republican Specialized Scientific and Practical Medical Center of Urology", Uzbekistan, Tashkent
Author
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- Keywords:
- urolithiasis, ureteral stones, tamsulosin, silodosin, α1-adrenergic blockers.
- Abstract
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Urolithiasis remains one of the most relevant problems in modern urology. Ureteral stones are often accompanied by severe pain and impaired urodynamics. In recent years, α1-adrenergic blockers have been widely used as medical expulsive therapy.
Objective. To comparatively evaluate the effectiveness of tamsulosin and silodosin in patients with urolithiasis and ureteral stones located in different segments of the ureter.
Materials and Methods. The study included 50 patients aged 20 to 60 years, divided into two groups: the tamsulosin group (n = 25) and the silodosin group (n = 25). The time to stone passage, severity of lower urinary tract symptoms, pain intensity, and effects on arterial blood pressure were assessed.
Results. The silodosin group demonstrated shorter stone expulsion times and a more pronounced reduction in lower urinary tract symptoms and pain compared with the tamsulosin group. No significant effect on arterial blood pressure was observed in either group.
Conclusion. Silodosin showed higher clinical efficacy in the medical treatment of ureteral stones compared with tamsulosin, with a comparable safety profile. - References
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- Published
- 2026-03-15
- Issue
- Vol. 2 No. 3 (2026)
- Section
- Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.
