STUDY OF CLINICAL AND LABORATORY FEATURES OF THE COURSE OF NON-DEVELOPING PREGNANCY OF THE ANEMBRYONIC TYPE IN THE FIRST TRIMESTER
- Authors
-
-
Uteniyazova D. K.
Department of Obstetrics and Gynecology Karakalpakstan Medical Institute
Author
-
Gafurova F.A.
Department of Obstetrics, Gynecology and Perinatal Medicine Center for the Development of Professional Qualifications of Medical Workers
Author
-
- Keywords:
- Non-developing pregnancy; anembryonia; embryonic demise; chromosomal abnormalities; infections; endometritis; reproductive loss; first trimester.
- Abstract
-
Non-developing pregnancy, particularly in the form of anembryonic pregnancy type I (AN I), remains a significant problem in reproductive medicine due to its high prevalence and multifactorial pathogenesis.
Anembryonic pregnancy type I accounted for 44% of cases. The majority of patients (75%) were aged 27–40 years, with two incidence peaks at 24–25 and 30–32 years. Chromosomal abnormalities were identified in 40% of cases, predominantly triploidy, while 60% of cases were associated with non-genetic factors. Infectious and inflammatory conditions, including STIs and chronic endometritis, were common and contributed to pregnancy failure. In 25% of patients, the clinical course was asymptomatic, emphasizing the key role of ultrasound diagnostics and β-hCG monitoring in early detection. - References
-
1.Acuña J, Rukh S, Adhikari S. Point-of-care ultrasound identification of yolk stalk sign in a case of failed first trimester pregnancy. World J Emerg Med. 2018;9(2):149-151. DOI: 10.5847/wjem.j.1920-8642.2018.02.012
2.Di Pietro C., Cicinelli E., Guglielmino M.R., Ragusa M., Farina M., et al. Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endometritis. // Am J Reprod Immunol. - 2013. - V.69,№5. - P.509-517. https://doi.org/ 10.1111/aji.12076
3.Kapfhamer J.D., Palaniappan S., Summers K., Kassel K., Mancuso A.C., et al. Difference between mean gestational sac diameter and crown-rump length as a marker of firsttrimester pregnancy loss after in vitro fertilization. // Fertil Steril. - 2018. - V.109,№1. - P.130-136. DOI: 10.1016/j. fertnstert.2017.09.031
4.Murugan VA, Murphy BO, Dupuis C, Goldstein A, Kim YH. Role of ultrasound in the evaluation of first-trimester pregnancies in the acute setting. // Ultrasonography. - 2020. - V.39,№2. - P.178-189. DOI: 10.14366/usg.19043
5.NICE guideline [NG126]. Ectopic pregnancy and miscarriage: diagnosis and initial management. Published date: 17 April 2019. Accessed at: https://www.nice.org.uk/ guidance/ng126.
6.Puscheck E.E., Scott Lucidi R. FACOG Early Pregnancy Loss Workup / Updated: Jun 08, 2018. - URL: https://reference. medscape.com/article/266317-workup
7.Sivko T.S., Andreeva M.V., Gadzhieva A.Kh. Non-developing pregnancy as a cause of reproductive losses. Almanac-2019: collection of articles. 2019:228-230. (In Russ.).
- Downloads
- Published
- 2026-03-24
- Issue
- Vol. 2 No. 3 (2026)
- Section
- Articles
- License
-
This work is licensed under a Creative Commons Attribution 4.0 International License.
