THE ROLE OF THE TNF-α GENE POLYMORPHIC VARIANT IN THE DEVELOPMENT OF PSORIASIS IN CHILDREN

Authors

  • Valiev Abduaziz Abdusamatovich

    PhD, Assistant Professor of the Department Department of Dermatovenereology and Pediatric Dermatovenereology, Tashkent State Medical University

    Author

Keywords:
psoriasis, children, TNF-α gene, genetic polymorphism, pathogenesis, allele, genotype.
Abstract

This study explores the genetic aspects of the etiopathogenesis of psoriasis in children. The research analyzed the distribution of alleles and genotypes of the single nucleotide polymorphism -308G>A of the TNF-α gene (rs1800629) in 107 affected children and 80 individuals in a control group. The results demonstrated a statistically significant prevalence of the heterozygous G/A genotype and the A allele in the patient group compared to the control group, which is associated with an almost twofold increase in the risk of disease development (OR=1.9). It was established that the presence of the A allele is associated with high TNF-α production and can serve as a genetic marker of susceptibility to psoriasis, whereas the G/G genotype plays a protective role. The findings suggest that the -308G>A polymorphism is a potential biomarker for risk prediction and assessment of psoriasis severity in pediatric practice.

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Published
2026-03-30
Issue
Vol. 2 No. 3 (2026)
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Articles
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How to Cite

THE ROLE OF THE TNF-α GENE POLYMORPHIC VARIANT IN THE DEVELOPMENT OF PSORIASIS IN CHILDREN. (2026). Eureka Journal of Health Sciences & Medical Innovation, 2(3), 344-352. https://eurekaoa.com/index.php/5/article/view/685