MIGRANE AND THE TRIGEMINAL SYSTEM: SUBJECTIVE PREMONITION OF ATTACK ONSET

Authors
  • Abdukodirov Eldor Isroilovich

    Department of Neurology and Traditional Medicine Tashkent State Medical University

    Author

  • Toshmurodov Sukhrobjon Musurmon ugli

    Department of Neurology and Traditional Medicine Tashkent State Medical University

    Author

  • Babakulov Sharaf Khamrakulovich

    Department of Neurology and Traditional Medicine Tashkent State Medical University

    Author

  • Mukhammedsaidova Iroda Abduvakhob kizi

    Department of Neurology and Traditional Medicine Tashkent State Medical University

    Author

Keywords:
Migraine, trigeminal system, prodrome, central sensitization, hypothalamus, headache
Abstract

The article examines the role of the trigeminal system in the pathogenesis of migraine, as well as the phenomenon of subjective premonition of attack onset. The prodromal period of migraine, its neurobiological mechanisms, and clinical significance are highlighted. The activation of the trigeminovascular system, central sensitization, and the involvement of the hypothalamus are analyzed. The significance of this phenomenon for early diagnosis and preventive therapy is substantiated.

References

1.Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017). Pathophysiology of migraine: A disorder of sensory processing. Physiological Reviews, 97(2), 553–622. https://doi.org/10.1152/physrev.00034.2015

2.Tessitore, A., Russo, A., Esposito, F., et al. (2020). Migraine and trigeminal system: I can feel it coming. Neurological Sciences, 41(Suppl 2), 371–376. https://doi.org/10.1007/s10072-020-04663-6

3.Абдукадиров, Э. И., Иноятова, С. О., Каланов, А. Б., & Абдуллаева, М. Б. (2026). Актуальные проблемы орофасциальной боли: Унифицированная международная классификация, молекулярные основы и перспективы терапии. Образование, наука и инновационные идеи в мире, 85(2), 208–224.

4.Matmurodov, R., & Abduqodirov, E. I. (2020). Depression in various forms of parkinsonism and striatal hyperkinesis. Movement Disorders, 35, S335.

5.Naimov, O., Abduqodirov, E. I., Matmurodov, R., & Khalimova, K. (2019). Constipation as a predictor of Parkinson’s disease in persons of Uzbek nationality. Journal of the Neurological Sciences, 405, 302. https://doi.org/10.1016/j.jns.2019.10.1404

6.Burstein, R., Noseda, R., & Borsook, D. (2015). Migraine: multiple processes, complex pathophysiology. Journal of Neuroscience, 35(17), 6619–6629. https://doi.org/10.1523/JNEUROSCI.0373-15.2015

7.Abdukodirov, E. I. (2025). Parkinson kasalligining klinik shakllarida immunologik, psixologik va neyrovizual o‘zgarishlarning kompleks tahlili. Вестник Ассоциации Пульмонологов Центральной Азии, 12(7), 24–26.

8.Tairova, D. Z., & Abduqodirov, E. I. (2024). Parkinson kasalligida klinik simptomlarni shakllanishida immunologik omillarning roli. Журнал гуманитарных и естественных наук, (17), 110–112.

9.Matmurodov, R., Khalimova, K., & Abduqodirov, E. I. (2019). Cardiovascular disorders in parkinsonism depending on the form of the disease. Journal of the Neurological Sciences, 405, 198–199.

10.Abduqodirova, M. B., Xodjibekova, Y. M., & Abdukodirov, E. I. (2022). Possibilities of ultrasound examination in the diagnosis of tunnel neuropathies of the upper limb. European Journal of Modern Medicine and Practice, 2(2), 17–21.

11.Isroilovich, A. E., Abdullayeva, M. B., Matmurodov, R. J., Khalimova, K. M., Muminov, B. A., & Naimov, O. Y. (2022). The role and importance of glial neurotrophical factors in early diagnosis of Parkinson disease. Texas Journal of Medical Science, 5, 1–6.

12.Abdukodirov, E. I., Khaydarov, N. K., & Matmurodov, R. Z. (2022). Analysis of risk factors in the etiopatogenesis of congenital myopathy syndrome. International Journal of Health Systems and Medical Science, 5(6), 148–155.

13.Charles, A. (2018). The pathophysiology of migraine: Implications for clinical management. The Lancet Neurology, 17(2), 174–182. https://doi.org/10.1016/S1474-4422(17)30435-0

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Published
2026-04-03
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How to Cite

MIGRANE AND THE TRIGEMINAL SYSTEM: SUBJECTIVE PREMONITION OF ATTACK ONSET. (2026). Eureka Journal of Health Sciences & Medical Innovation, 2(3), 397-403. https://eurekaoa.com/index.php/5/article/view/716