MICROBIOTA AND IMMUNE REGULATION IN FREQUENTLY ILL CHILDREN
- Authors
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Nargiza F. Nurmatova
Tashkent State Medical University, Tashkent, Republic of Uzbekistan
Author
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- Keywords:
- Intestinal microbiota, immune regulation, frequently ill children, dysbiosis, secretory IgA, IL-6.
- Abstract
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Introduction. The intestinal microbiota plays a pivotal role in the development and regulation of the child’s immune system. Alterations in its composition may contribute to immune dysfunction and increased susceptibility to infectious diseases.
Objective.To investigate the role of the intestinal microbiota in immune response regulation in frequently ill children.
Materials and methods. A comparative clinical and laboratory study was conducted alongside an analysis of current scientific literature on intestinal microbiota and immune regulation in children. The study included 52 frequently ill children aged 3–12 years and 30 apparently healthy children in the control group. The composition of intestinal microbiota, frequency of acute respiratory infections (ARIs), and selected immunological parameters were assessed.
Results. Frequently ill children exhibited a significant decrease in Bifidobacterium and Lactobacillus, along with an increased proportion of opportunistic microorganisms. These changes were accompanied by decreased levels of secretory IgA and elevated IgE and IL-6. A significant association was found between microbiota imbalance, altered immune status, and increased frequency of ARIs. - References
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- Published
- 2026-04-07
- Issue
- Vol. 2 No. 4 (2026)
- Section
- Articles
- License
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This work is licensed under a Creative Commons Attribution 4.0 International License.
