NEUROREGENERATION BEYOND NEUROPROTECTION: A NEW FRONTIER IN ALZHEIMER’S DISEASE RESEARCH:THE ZEBRAFISH PARADIGM
- Authors
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Dr. Aman Khandelwal
Assistant Teacher, Samarkand State Medical University, Uzbekistan
Author
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Arish Husain
Author
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Anam Husain
Author
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- Keywords:
- Alzheimer’s disease, neuroregeneration, neuroprotection, zebrafish (Danio rerio), adult neurogenesis, neural stem cells, amyloid-β42, glial plasticity, interleukin-4, translational neuroscience, disease-modifying therapy
- Abstract
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Alzheimer’s disease (AD) represents the most prevalent neurodegenerative disorder worldwide, characterized by progressive neuronal loss, synaptic failure, and the pathological accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. For decades, the therapeutic landscape has been dominated by neuroprotection—strategies aimed at shielding existing neurons from further damage. However, the sobering reality of clinical trials reveals a critical limitation: neuroprotection alone cannot reverse the neuronal devastation already wrought by the disease. As of 2026, over 200 drug candidates have failed in Phase III trials, with most approaches focusing on amyloid clearance or anti-inflammatory modulation without addressing the fundamental deficit of neuronal replacement.
- References
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1.Bhattarai P, et al. The effects of aging on Amyloid-β42-induced regenerative neurogenesis in adult zebrafish brain. Cell Reports. 2017;19(7):1287-1295.
2.Kizil C, et al. More neurons, less Alzheimer’s: from zebrafish to mammals. Springer Nature Communities. 2023.
3.Pradhan LK, et al. Zebrafish neural regeneration: mechanistic insights into human nervous system repair. Neuroscience. 2026.
4.Bhattarai P, et al. Is Alzheimer’s also a stem cell disease? – The zebrafish perspective. Frontiers in Neuroscience. 2018;12:6.
5.Franco R. Neuroprotection beyond neurons: integrated biomarker-based and astroglia- or microglia-targeted approaches to combat neurodegenerative diseases. Exploration of Neuroprotective Therapy. 2026;6:1004136.
6.Grandel H, Brand M. Neural stem cells and neurogenesis in the adult zebrafish brain. Developmental Biology. 2013.
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- Published
- 2026-04-28
- Issue
- Vol. 2 No. 4 (2026)
- Section
- Articles
- License
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Copyright (c) 2026 Dr. Aman Khandelwal, Arish Husain, Anam Husain (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
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